C-reactive protein and lipoprotein-a as markers of coronary heart disease in polycystic ovary syndrome

Abstract

OBJECTIVE: The aim of this study was to investigate the risk factors of coronary heart disease, CRP and Lipoprotein-a in polycystic ovary syndrome patients. MATERIAL AND METHODS: Prospectively collected data of polycystic ovary syndrome patients (n=62) and control group (n=40) were compared. RESULTS: PCOS patients had higher HOMA-IR, CRP, DHEAS, free testosterone, FAI, LH and prolactin levels when compared to the control group. Lipoprotein-a levels did not differ between the groups. The obese PCOS group had statistically significantly higher fasting blood glucose, total cholesterol, triglyceride, free testosterone, insulin, CRP and HOMA-IR and statistically significantly lower HDL and SHBG when compared to normal weight PCOS persons. Fasting blood glucose, total cholesterol, LDL, SHBG, CRP, Lipoprotein-a, FSH, LH, TSH, DHEAS and prolactin levels did not differ between the normal weight and obese control groups. CONCLUSION: CRP levels increase in polycystic ovary syndrome patients and can be used as a marker of coronary heart disease. Future studies can be directed at treatments to decrease CRP levels, including antiinflammatory treatments.

Amaç: Bu çalışmanın amacı polikistik over sendromlu hastalarda koroner kalp hastalıkları risk faktörlerini, CRP ve Lipoprotein-a araştırmaktı. Gereç ve Yöntemler: Prospektif olarak polikistik over sendromlu (n=62) ve kontrol grubunun (n=40) kan örnekleri çalışıldı. Bulgular: Polikistik over sendromlu hastalarda HOMA-IR, CRP, DHEAS, serbest testosteron, FAI, LH and prolaktin seviyeleri yüksek, FSH ve SHBG seviyeleri ise düşük bulundu. Lipoprotein-a gruplarda farklı değildi. Obez polikistik over sendromlu hastalarda açlık kan şekeri, total kolesterol, trigliserit, serbest testosteron, insulin, CRP ve HOMAIR daha yüksek, HDL ve SHBG daha düşük bulundu. Açlık kan şekeri, total kolesterol, LDL, CRP, SHBG, Lipoprotein-a, FSH, LH, TSH, DHEAS ve prolaktin seviyeleri obez ve normal kilolu kontrol gruplarında benzerdi