The effect of IL-1B and specific ice/caspase-1 bloker on spike-and-wave discharges
Künye
Akin D, Ravizza T, Morosso M, Carcak N, Eryigit T, Vanzulli I, Gulhan Aker R, Vezzani A, Onat Yilmaz F. The fffect of IL-1B and specific ice/caspase-1 bloker on spike-and-wave discharges. Epilepsia. 2011; 52(suppl 6): 61. 29th International Epilepsy Congress Location: Rome, Italy, AUG 28-SEP 01, 2011Özet
Purpose: Interleukin (IL)-1b plays a crucial role in the mechanisms of limbic seizures induced in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1b signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-andwave discharges (SWDs). Moreover, we studied whether inhibition of IL-1b biosynthesis could affect SWD activity.
