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dc.contributor.authorAçıkgöz, Birkan
dc.contributor.authorKaraltı, İskender
dc.contributor.authorErsöz, Melike
dc.contributor.authorCoşkun, Zeynep Mine
dc.contributor.authorÇobanoğlu, Gülşah
dc.contributor.authorSesal, Cenk
dc.date.accessioned2015-09-09T09:11:05Z
dc.date.available2015-09-09T09:11:05Z
dc.date.issued2013
dc.identifier.citationAçikgöz B, Karalti I, Ersöz M, Coşkun ZM, Cobanoğlu G, Sesal C. Screening of antimicrobial activity and cytotoxic effects of two Cladonia species. Z Naturforsch C. 2013; 68(5-6): 191-7.en_US
dc.identifier.issn0939-5075
dc.identifier.urihttp://www.degruyter.com/en_US
dc.identifier.urihttps://hdl.handle.net/11446/763en_US
dc.descriptionİstanbul Bilim Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu.en_US
dc.description.abstractThe present study explores the antimicrobial activity and cytotoxic effects in culture assays of two fruticose soil lichens, Cladonia rangiformis Hoffm. and Cladonia convoluta (Lamkey) Cout., to contribute to possible pharmacological uses of lichens. In vitro antimicrobial activities of methanol and chloroform extracts against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus), and the yeast Candida albicans were examined using the paper disc method and through determination of minimal inhibitory concentrations (MICs). The data showed the presence of antibiotic substances in the chloroform and the methanol extracts of the lichen species. The chloroform extracts exhibited more signifi cant antimicrobial activity than the methanol extracts. However, a higher antifungal activity was noted in the methanol extract of C. rangiformis. The maximum antimicrobial activity was recorded for the chloroform extract of C. convoluta against E. coli. The cytotoxic effects of the lichen extracts on human breast cancer MCF-7 cells were evaluated by the trypan blue assay yielding IC50 values of ca. 173 and 167 μg/ml for the extracts from C. rangiformis and C. convoluta, respectively.en_US
dc.language.isoengen_US
dc.publisherDe Gruyteren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlichenen_US
dc.subjectantimicrobial activityen_US
dc.subjectMCF-7en_US
dc.subjectcladoniaen_US
dc.titleScreening of antimicrobial activity and cytotoxic effects of two Cladonia species.en_US
dc.typearticleen_US
dc.relation.journalZeitschrift fur Naturforschung Cen_US
dc.departmentDBÜ, Sağlık Hizmetleri Meslek Yüksekokuluen_US
dc.identifier.issue5-6
dc.identifier.volume68
dc.identifier.startpage191
dc.identifier.endpage197
dc.contributor.authorIDTR34940en_US
dc.contributor.authorIDTR104953en_US
dc.contributor.authorIDTR20651en_US
dc.contributor.authorIDTR191549en_US
dc.relation.publicationcategoryBelirsizen_US


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