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Emerin expression in well differentiated epithelial lesions of thyroid: implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior

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Date

2015

Author

Çoban, Ipek
Çakır, Asli
Kökenek Ünal, Tuba Dilay
Başsüllü, Nuray
Karpuz, Vildan
Bülbül Doğusoy, Gülen
Alper, Murat

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Citation

Coban I, Cakir A, Unal TD, Bassullu N, Karpuz V, Dogusoy GB, Alper M. Emerin expression in well differentiated epithelial lesions of thyroid: implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior. Pathol Oncol Res. 2015; 21(2): 357-366. doi: 10.1007/s12253-014-9828-0

Abstract

Recently, it has been reported that identifying nuclear membrane irregularities with anti-emerin antibody is useful for papillary thyroid carcinoma diagnosis. However, literature regarding the significance of emerin immunohistochemistry in thyroid is limited. We evaluated the diagnostic accuracy of the well-established nuclear alterations, nuclear protrusions and recently described nuclear shapes (garlands and star-like shapes) with emerin immunohistochemistry and hematoxylin- eosin stain in thyroid lesions. We further evaluated the diagnostic accuracy measures of tissue microarrays evaluated with both stains, to detect whether emerin immunohistochemistry improves the diagnostic accuracy for papillary thyroid carcinoma.

Source

Pathology and Oncology Research

Volume

21

Issue

2

URI

http://link.springer.com/
https://hdl.handle.net/11446/824

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  • Tıp Fakültesi Makale Koleksiyonu [440]



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