Association study of the DIO2 gene as a susceptibility candidate for schizophrenia in the Turkish population; A case-control study
Citation
Colak A, Akan G, Oncu F, Yanbay H, Acar S, Yesilbursa D, Turkcan S, Atalar F. Association study of the dio2 gene as a susceptibility candidate for schizophrenia in the turkish population; a case-control study. European Psychiatry. 2013;28(Suppl.1). 21st European Congress of Psychiatry (EPA) Nice, France, 6-9 April 2013. doi:10.1016/S0924-9338(13)76526-XAbstract
Introduction: Schizophrenia (SCH) is one of the major and potentially severe mental illness that is characterized by both genetic and clinical heterogeneity. Thyroid hormone plays an important role in the development of the brain and nervous system both in the basic process of neurogenesis and of terminal brain differentiation. Type II deiodinase (DIO2) enzyme which has a critical role on thyroid hormone metabolism to convert pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3). Recently, DIO2 gene variations have been identified in association with mental disorders.
