mRNA expression levels of elastin, fibulin-5, LOXL-1, MMP-2 and MMP-9 in patients with varicose vein

Abstract

Aim: The reason of varicose vein formation is not exactly known yet; but some morphological and physiological changes of venous wall are thought to be responsible. One of those suspected reasons is the changes in quantity and content of elastin protein. There are some recent researches about elastin protein in various other diseases, but there is not enough comprehensive investigations about the mechanisms of elastin assembly in varicose vein formation. In this study, we aimed to investigate the changes in mRNA levels of elastin and some of its related proteins in formation of varicose veins.