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dc.contributor.authorSöğüt, İbrahim
dc.contributor.authorErsöz, Melike
dc.contributor.authorPaltun, Sıla Özlem
dc.contributor.authorSavaşan Söğüt, Melis
dc.contributor.authorHürdağ, Canan
dc.date.accessioned2016-01-19T12:27:41Z
dc.date.available2016-01-19T12:27:41Z
dc.date.issued2015
dc.identifier.citationSogut I , Ersoz M , Paltun SO 3, Savasan Sogut M, Hurdag C. The antioxidant effect of boric acid in chronic alcohol abuse. 40th FEBS Congress, The Biochemical Basis of Life, July 4-9 2015, Berlin, Germanyen_US
dc.identifier.urihttps://hdl.handle.net/11446/888en_US
dc.descriptionİstanbul Bilim Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu.en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.descriptionİstanbul Bilim Üniversitesi, Fen Edebiyat Fakültesi.en_US
dc.description.abstractAlcohol is a toxin that causes serious damage on many organs depending on the dose and duration of use. Chronic alcohol consumption is the most important factor that leads to cirrhosis and liver failure. In this study, oxidative stress that was generated due to chronic alcohol intake and the protective effect of boric acid was evaluated. Experimental animals were divided into four groups: control, alcohol, alcohol+boric acid and boric acid. The levels of alcohol-induced oxidative stress indicators malondialdehyde ((MDA), total sialic acid (TSA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)) were measured in liver tissues. While the MDA and TSA levels increased significantly in the alcohol group compared to the control group (p<0.05, p<0.01), that of the alcohol+boric acid group decreased significantly compared to the alcohol group (p<0.01, p<0.001). The TSA level was significantly low in the boric acid group as compared to the alcohol group (p<0.001). In the alcohol group, SOD and GPx activities were significantly lowered (p<0.01, p<0.001), while there was an increase in that of the alcohol + boric acid group compared to the alcohol group (p<0.01, p<0.05). SOD and GPx activities increased significantly in the boric acid group compared to the alcohol group (p<0.01, p<0.001). There was no significant difference between the groupsen_US
dc.language.isoengen_US
dc.publisherFederation of European Biochemical Societiesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe antioxidant effect of boric acid in chronic alcohol abuseen_US
dc.typeconferenceObjecten_US
dc.relation.journal40th FEBS Congress, The Biochemical Basis of Lifeen_US
dc.contributor.departmentDBÜ, Sağlık Hizmetleri Meslek Yüksekokuluen_US
dc.contributor.authorIDTR25639en_US
dc.contributor.authorIDTR104953en_US
dc.contributor.authorIDTR51698en_US
dc.relation.publicationcategoryBelirsizen_US


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